![]() ![]() It has been recognized as a subversive technique for pathogen detection, especially for rare and complex infectious diseases. Metagenomic next-generation sequencing (mNGS) is a powerful pathogen detection approach that can potentially diagnose nucleic acids (DNA and RNA) of all infectious diseases, including bacteria, fungi, viruses, and parasites, in a single test. Therefore, there is an urgent need for a series of more powerful pathogen detection tools. Traditional detection methods cannot effectively address them. However, these methods have many limitations, such as long detection cycles, low sensitivity, and narrow detection spectrum of pathogens, especially for infections caused by rare or new pathogens. The traditional etiological diagnosis methods of infection mainly include morphological identification, microbial culture, smear microscopic examination, antigen and antibody detection, nucleic acid detection, etc. Therefore, etiological detection technology is required to achieve timely, accurate, and comprehensive detection of pathogens. The diagnosis and treatment depend on etiological detection techniques. The incidence of infectious diseases is high and often causes critical illness, which seriously threatens human life and health. In this Research Topic of Frontiers in Microbiology, we assembled a collection of 12 original research articles and 2 reviews within the theme “ Molecular Diagnostics for Infectious Diseases: Novel approaches, Clinical Applications and Future Challenges.” The intended goal of this Research Topic was to present an updated view of current innovations in molecular diagnostics and challenges against clinical pathogens. ![]()
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